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1 article(s) from Kassler, Kristin

Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120

Julia Meier,
Kristin Kassler,
Heinrich Sticht and
Jutta Eichler

Beilstein J. Org. Chem. 2012, 8, 1858–1866, doi:10.3762/bjoc.8.214

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Graphical Abstract

Figure 1: Structural details of the CD4–gp120 complex (pdb 1rzj). The binding site of CD4 for gp120 is shown ...

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Figure 2: HPLC chromatograms and ion masses from the ESI-mass spectra (insets) of purified CD4-M2 (M = 5979.8...

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Figure 3: Left: Relative affinities (A_r, CD4-M1 = 1) to gp120(IIIB) of peptides. Right: Concentration-depende...

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Figure 4: Enhancement of binding of gp120(MN) to the CD4i antibody X5 by CD4-M5 and sCD4, respectively. See E...

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Figure 5: Conformational stability of CD4 mimetic peptides in complex with gp120 during 20 ns of MD simulatio...

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Figure 6: Structural presentation of peptide motions in the gp120-bound state during the MD simulation. (A) C...

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Full Research Paper

Published 31 Oct 2012

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